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Brief report: Reducing Lorlatinib-related Adverse Events by establishing the Optimal Exposure-Toxicity Threshold in Patients with NSCLC.
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Lanser DAC, van Merendonk LN, Veerman GDM, van Beusekom S, Hoop EO, de Bruijn P, Icli A, Paats MS, Huitema ADR, van Schaik RHN, Badrising S, Dingemans AC, Mathijssen RHJ
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42462816
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16-07-2026
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04-08-2026
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De adviezen van de klinisch chemicus en het medisch tuchtrecht
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Schindhelm RK, Wierda E, Elias NS
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25-06-2026
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02-07-2026
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Real-World Impact of UGT1A1 Genotype-Guided Irinotecan Dosing on Severe Toxicity and Hospitalization: A Multicenter Study.
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Heersche N, Peeters SLJ, Böhm D, Böhringer S, Guiljam R, Hulshof EC, de Man FM, de With M, Joosse M, Oomens G, Wu QY, Bins S, van Hellemond IEG, Haberkorn BCM, Verschoor AJ, Wumkes ML, Thijs AM, van Schaik RHN, Gelderblom H, Guchelaar HJ, Mathijssen RHJ, Deenen MJ
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42276133
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Pharmacokinetics of 5-Fluorouracil in Patients Treated With Capecitabine Carrying the c.1236G>A DPYD Variant Allele.
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Heersche N, Knikman JE, Deenen MJ, Rosing H, van Schaik RHN, Beijnen JH, Schellens JHM, Gelderblom H, Guchelaar HJ, Swen JJ, Cats A, Mathijssen RHJ, Jacobs BAW
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42258784
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From evidence to implementation: key priorities for pharmacogenomics-guided treatment and prevention from a European expert workshop.
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Kreeftenberg LL, Henneman L, Rigter T, Gris AV, LLerena A, McDermott JH, Rutten-van Mölken M, Vicente AM, van Schaik RHN, Sharma V, Swen JJ, Cornel MC, van El CG
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42209751
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28-05-2026
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Novel SERPINC1 variants in hereditary antithrombin deficiency: first pathogenic deep-intronic variant, revealed by multiple genomic and transcriptomic approaches.
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Remmelzwaal PC, Mulder R, de Boer-Bergsma JJ, Vinke A, Kooistra HAM, Veeger NJGM, Wierenga ATJ, Schuringa JJ, Lukens MV, Meijer K
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42202885
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26-05-2026
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Sex Impacts Progression-Free Survival of Alectinib through Drug Exposure in Patients with ALK-Positive Non-Small Cell Lung Cancer.
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Lanser DAC, Heersche N, Muntinghe-Wagenaar MB, Ali MIM, Ulas EB, de Jonge E, Hoop EO, Paats MS, Bahce I, Croes S, Langen AJ, Hendriks LEL, Wekken AJ, Huitema ADR, Schaik RHN, Dingemans AC, Veerman GDM, Mathijssen RHJ
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42179890
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21-05-2026
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04-08-2026
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Assessing the responsiveness of musculoskeletal tissues to protein supplementation in vivo in older adults: an exploratory randomized controlled trial.
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Houtvast DC, Hendriks FK, Weijzen ME, Zorenc AH, Smeets JS, Emans PJ, Wodzig WK, Larsen MS, Mikkelsen UR, Schotanus MG, Boonen B, van Mulken JM, de Leeuw PA, van Stijn MF, Baar K, van Loon LJ
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42142739
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15-05-2026
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01-06-2026
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The role of cytochrome P450 polymorphisms in the pharmacokinetics of oral esketamine.
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Coerts DT, Smith-Apeldoorn SY, Oude Nijhuis JC, van Schaik RHN, Tamminga WJ, Touw DJ, Veraart JKE, Schoevers RA, van Dalfsen JH
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42031731
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24-04-2026
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04-05-2026
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Prospective clinical evaluation of cell-free DNA next generation sequencing in patients with suspected metastatic lung cancer.
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Steendam CMJ, Meijers RWJ, Atmodimedjo P, van Dijk L, van der Leest C, van Loenhout KCJ, van 't Westeinde SC, Dumoulin DW, Hanselaar WEJJ, Paats MS, de Jonge E, van Schaik RHN, von der Thüsen JH, Aerts JGJV, Dingemans AC, Dubbink HJ
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41951723
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08-04-2026
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Leucine supplementation does not attenuate the decline in daily muscle protein synthesis rates or preserve leg muscle mass during leg immobilization in young or older adults: a double-blind randomized trial.
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Churchward-Venne TA, Pinckaers PJ, Smeets JS, Marzuca-Nassr GN, Gorissen SH, Fuchs CJ, Senden JM, Goessens JP, Gijsen AP, Wodzig WK, van Loon LJ
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41580240
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01-04-2026
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13-04-2026
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Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene-drug interaction between CYP2D6 and CYP2C19 and tricyclic antidepressants.
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Kleine Schaars K, Nijenhuis M, Soree B, de Boer-Veger NJ, Buunk AM, Guchelaar HJ, Houwink EJF, Risselada A, Rongen GAPJM, van Schaik RHN, Swen JJ, Touw D, Deneer VHM, van Westrhenen R
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41526670
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01-03-2026
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04-05-2026
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Interaction of CYP2C19 with the effect of clopidogrel in secondary prevention of major ischemic events: Systematic review and meta-analysis.
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Kremers FC, van den Biggelaar J, Lingsma HF, van Schaik RH, Roozenbeek B, Dippel DW
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40844153
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01-03-2026
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04-05-2026
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Sex differences in outcomes of vitamin K antagonist treatment in patients with a mechanical heart valve: a Dutch population-based cohort study.
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Kempers EK, Visser C, Seelig J, Chen Q, Adriaansen HJ, Beinema MJ, Ten Cate-Hoek AJ, Faber LM, Dronkers CEA, Nierman MC, Schindhelm RK, Wiersma NM, Stork ADM, Klok FA, Leebeek FWG, Pisters R, Cannegieter SC, De Caterina R, Hemels MEW, Ten Cate H, Kavousi M, Kruip MJHA
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41072734
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01-03-2026
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16-04-2026
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Genotype-Guided P2Y(12)-Inhibitor De-Escalation Strategy in Acute Coronary Syndrome: Observational Evidence From the POPular-GUIDE PCI.
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van den Broek WWA, Azzahhafi J, van de Pol QYF, Chan Pin Yin DRPP, van der Sangen NMR, Sivanesan S, Peper J, Harmsze AM, Walhout RJ, Tjon Joe Gin M, Breet NJ, Langerveld J, Appelman Y, van Schaik RHN, Henriques JPS, Kikkert WJ, Ten Berg JM
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41744086
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26-02-2026
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04-05-2026
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Survival of patients with colorectal or pancreatic cancer who received UGT1A1 genotype-guided dosing of irinotecan in the Netherlands (2017-2024): a retrospective, multicentre cohort study.
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Peeters SLJ, Heersche N, Böhm D, Böhringer S, Guiljam R, Hulshof EC, de Man FM, de With M, Joosse M, Oomens G, Wu QY, Osman A, Bins S, van Hellemond IEG, Haberkorn BCM, Verschoor AJ, Wumkes ML, van Schaik RHN, Thijs AM, Gelderblom H, Guchelaar HJ, Mathijssen RHJ, Deenen MJ
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41777427
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23-02-2026
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04-05-2026
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Antenatal risk estimation for exchange transfusions in neonates with hemolytic disease of the fetus and newborn in a changing treatment landscape: A multicenter, retrospective cohort study.
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de Winter DP, de Haas M, Hulzebos CV, Lukens MV, Prins SA, Been JV, d'Haens EJ, Vijlbrief DC, Vrancken SLAG, Trompenaars AMP, Ceelie H, van Zogchel LMJ, Joosen AMCP, Meijssen CB, van Hillegersberg JLAM, Zant JC, van Rossem MC, van Beek R, Stas HG, Counsilman CE, Knol FR, Schiering IAM, Dubbink-Verheij GH, Verweij EJT, Lopriore E, WISE investigators
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41468257
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01-02-2026
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30-07-2026
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Global Investigation of Clinical Implementation Strategies for DPYD Testing to Guide Fluoropyrimidine Therapy.
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El Rouby N, Aquilante CL, Bargal SA, Cavallari LH, Duarte JD, Gunderson K, Mazhindu T, Nagy M, Nie X, Nguyen DG, Patel JN, Skaar TC, Smith DM, Tuteja S, van Schaik RHN, Hicks JK, PGRN Implementation Working Group
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41456101
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01-01-2026
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04-05-2026
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Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene-drug interaction between TPMT/NUDT15 and thiopurines.
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Coenen MJH, Nijenhuis M, Soree B, de Boer-Veger NJ, Buunk AM, Guchelaar HJ, Houwink EJF, Risselada A, Rongen GAPJM, Swen JJ, Touw DJ, van Westrhenen R, Deneer VHM, van Schaik RHN
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41318725
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01-01-2026
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04-05-2026
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The 8th European Society of Pharmacogenomics and Personalized Therapy (ESPT) congress.
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van Schaik RHN, Swen JJ, Llerena A, Koch BCP, Coenen MJH, Molden E, Mathijssen RHJ, Cecchin E, Wadelius M, van Gelder T, Picard N, Daly AK, Stanković S, van den Broek D, Rodriguez-Antona C, Matic M, Cascorbi I, van der Lee M, Dolzan V, Morris T, Niemi M
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41924848
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01-01-2026
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04-05-2026
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Sex-based differences in biomarker trajectories in acute coronary syndrome patients from the BIOMArCS study.
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Gärtner C, Haaf MET, Akkerhuis KM, Oemrawsingh RM, van Schaik RH, de Rijke YB, Kardys I, Appelman Y, Boersma E
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41372369
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10-12-2025
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04-05-2026
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ATP-binding cassette transporter polymorphisms and the pharmacokinetics of oral esketamine.
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Oude Nijhuis JC, Coerts DT, van Dalfsen JH, Smith-Apeldoorn SY, Veraart JKE, Schoevers RA, Touw DJ, van Schaik RHN, Tamminga WJ
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41560413
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01-12-2025
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04-05-2026
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Machine learning for risk stratification in the emergency department (MARS-ED): a randomized controlled trial.
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van Dam PMEL, van Doorn WPTM, Sevenich L, Lambriks L, Cals JWL, Bekers O, Stassen PM, Meex SJR
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41326390
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01-12-2025
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07-04-2026
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The Dutch HbA1c Lifestyle Study (DAF-Study): Seasonal Variation of HbA1c in the Dutch Diabetes Population - Associations with Macronutrient Intake and Physical Activity.
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Erwin Kemna, Henk Bilo, Martine Deckers, Christiaan Slim, Annemarieke Loot, Linda M. Henricks, Jacoline Brinkman, Jody van den Ouweland, Steef Kurstjens, Madeleen Bosma, Iris van Vlodrop, Pauline Verschuure, Jurgen Kooren, Stefan Coolen, Karin Mohrmann, Martin Schuijt, Johannes Krabbe, Robert Wever, Marlies Oostendorp, Ivon van der Linden, Margriet van Kogelenberg, Margo Molhoek, Mieke Koenders, Silvia Endenburg, Roseri de Beer, Cas Weykamp.
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03-11-2025
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27-05-2026
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Predicting metabolic preferences through transcriptomics: a data-driven approach to align metabolic signatures with gene expression profiles.
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Lerink LJS, de Winter MJ, Bakker JA, Alwayn IPJ, Ploeg RJ, Mulvey JF, Lindeman JHN
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41189637
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22-10-2025
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09-04-2026
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