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On November 5-8, 2025, the European Society of Pharmacogenomics and Personalized Therapy (ESPT) organized its 8th biennial congress, this time in Rotterdam, The Netherlands (www.esptcongress.org). The congress aimed to address the current status and future perspectives of pharmacogenomics, share the latest knowledge in this field of precision medicine and showcase the implementation of clinical applications in pharmacogenomics/pharmacogenetics. The 4-day congress consisted of in total 60 lectures given by key-opinion leaders, divided in 11 sessions, and included four national mini-symposia, two poster sessions of in total 160 posters and a discussion forum. The successful event enabled the exchange of information between 514 participants from 42 different countries and 20 industry partners on the current use, future aspects, and challenges of pharmacogenetics and its clinical implementation.