Nederlandse Vereniging voor Klinische Chemie en Laboratoriumgeneeskunde
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Project 351 Rac1/pSTAT3, a promising biomarker to predict thiopurine therapy response.
Onderzoekslijn Rac1 as a first pharmacodynamic marker to optimize IBD therapy
Omschrijving Inflammatory bowel disease (IBD) is a condition that is characterised by chronic inflammation of the
bowel. Crohn’s disease (CD) and ulcerative colitis (UC) are the most common IBD conditions.1-4
Current therapies are mainly focussed on the suppression of the overactive immune system to
induce and maintain remission of disease for the improvement of the quality of life for the patient.
Different types of medication can be prescribed: aminosalicylates, corticosteroids,
immunomodulators, antibiotics and biologic therapies.5 Currently, therapy response from the
immunomodulator thiopurine is measured by determining the thiopurine concentration in red blood
cells (RBC) while their mechanism of action is in white blood cells (WBC). Thiopurines target the Rasrelated
C3 tobulinum toxin substrate 1 (Rac1) signalling pathway, causing T-cell apoptosis.6 To
determine and predict therapy response more precisely, a multiparameter flow cytometric assay for
the detection of Rac1 and phosphorylated Signal Transducer and Activator of Transcription 3
(pSTAT3) in WBC was developed.
Projectleider Dr.ing. M.P.G.(Math) Leers
Instituut Zuyderland locatie Brunssum Brunssum
Trefwoorden pSTAT3
Status Lopend
Periode 1-2018 - 1-2024
Partners - Dr. A. Bodegraven, MDL-arts, Zuyderland MC
- Dr. D. Wong, apotheker, Zuyderland MC
Medewerkers - Kelly Pelzer, HLO-stagiaire Zuyd Hogeschool
- Marisa v Ampt, HLO-stagiaire Zuyd Hogeschool
- drs. D. Deben, apotheker i.o. Zuyderland
- dr. A. v. Adrichem. KCio
Financiering 1e Geldstroom - Intern

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