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Project 350 Determination of Rac1 presence and expression in leucocytes by a flow cytometric assay
Onderzoekslijn Rac1 as a first pharmacodynamic marker to optimize IBD therapy
Omschrijving The number of patients with IBD is increasing worldwide. IBD is a chronic inflammation of the gastro-intestinal tract and consists of two main diseases: Crohn’s disease and ulcerative colitis. Thiopurines are established to be effective for inducing and maintaining a long-term remission in IBD patients. However, up to half of the IBD patients discontinue thiopurine therapy within two years mostly due to intolerable side effects or ineffectiveness. The protein Rac1 is involved in the regulation of the immune response and is a target molecule of thiopurines. Previous research suggests that Rac1 is involved in the (dys)regulation of the inflammation reaction of IBD. Moreover, it is hypothesized that patients with genetic variants of Rac1 have a bad response on treatment with thiopurines. The aim of this study was to develop and perform a multiparameter flow cytometric assay for the determination of Rac1 presence (quantitative) and Rac1 expression (qualitative) in different leucocyte subtypes in peripheral blood. The research question was: Can Rac1 serve as a potential biomarker to predict the response to thiopurine therapy?
Projectleider Dr.ing. M.P.G.(Math) Leers
Instituut Zuyderland locatie Brunssum Brunssum
Trefwoorden
Status Afgesloten
Periode 1-2017 - 1-2018
Partners - Dr. A. Bodegraven, MDL-arts Zuyderland
- Dr. D. Wong, apotheker, Zuyderland
Medewerkers - Sabine Puts, HLO studente, Zuyd Hogeschool
- drs. D. Deben, apotheker i.o., Zuyderland
Financiering 1e Geldstroom - Intern

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