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Project 348 Ki-67, a forgotten marker with prognostic value, could be useful for predicting prognosis in MDS and MPN patients
Onderzoekslijn Proliferative activity in hematologic disorders
Omschrijving Myelodysplastic syndromes (MDS) and myeloproliferative neoplasms (MPNs) and acute myeloid leukaemia (AML) are a group of haematological malignancies that affect the blood and bone marrow (BM). The prevalence of MDS and MPNs is rising, due to the increasing life-expectancy and the greying of the society. This makes MDS and MPNs a pressing problem. The heterogeneity within the phenotypes of MDS/MPN diseases creates difficulties for predicting the prognosis of patients. Therefore, there is a need for improvement of the prediction of prognosis for these patients. Thus, the research question of this study is: can we predict the prognosis of patients with a myeloid bone marrow malignancy?
The proliferation marker Ki-67 is widely used within the field of pathology as a prognostic marker for several types of solid cancers. In contrast, use of this marker for prognostic and/or diagnostic purposes in flow cytometric (FCM) analysis of hematologic neoplasms is sparse. Since the usage of Ki-67 in flow cytometric analysis is sparse, the prognostic value of Ki-67 for haematological malignancies is yet to be determined. Therefore, We hypothesize that flow cytometric analysis of various CD markers and the proliferative marker Ki-67 predicts the prognosis of MDS, MPN, MDS/MPN and AML patients.
Projectleider Dr.ing. M.P.G.(Math) Leers
Instituut Zuyderland locatie Brunssum Brunssum
Trefwoorden CMMoL
Status Lopend
Periode 1-2018 - 1-2024
Partners UM Maastricht: prof.dr. F.C.S. Ramaekers en dr. A.H.N. Hopman. afd. Moleculaire Celbiologie & Genetica, GROW
MUMC+: dr. N.C.J. de Wit
Medewerkers Stefan Mestrum, PhD student UM/Zuuderland, GROW
Financiering 1e Geldstroom - Intern

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