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Project 70	Troponine T en fragmentatie
Onderzoekslijn	Cardiac markers bij acute coronaire syndromen
Omschrijving
Projectleider	Prof.dr. M.P.(Marja) van Dieijen-Visser
Instituut	Maastricht Universitair Medisch Centrum Maastricht
Trefwoorden	Troponine , NT proBNP cardiac markers
Status	Lopend
Periode	1-1996 - 1-2015
Partners
Medewerkers
Financiering	1e Geldstroom - Intern projectgeld en 1ste geldstroom Stichting Sint Annadal Stichting de Weijerhorst
Publicaties	Investigation of release and degradation of cardiac troponin T in patients with acute myocardial infarction. Highly sensitive immunoprecipitation method for extracting and concentrating low-abundance proteins from human serum. Comment on: Ann Clin Biochem. 2004 Jan;41(Pt 1):1-9. Impaired renal clearance explains elevated troponin T fragments in hemodialysis patients. The role of troponin T in the quantification of ischemic myocardial injury Evaluation of "new" cardiac markers for ruling out myocardial infarction after coronary artery bypass grafting. Size-exclusion chromatography of circulating cardiac troponin T. Interpretation of cardiac troponin T behaviour in size-exclusion chromatography. Temporal patterns of electrical remodeling in canine ventricular hypertrophy: focus on IKs downregulation and blunted beta-adrenergic activation. Cardiac troponin T degradation after acute myocardial infarction. Implications of cardiac troponin T degradation Heterogeniteit van circulerend cardiaal troponine T Cardiac troponin T release after prolonged strenuous exercise. Release kinetics of intact and degraded troponin I and T after irreversible cell damage. Reference population and marathon runner sera assessed by highly sensitive cardiac troponin T and commercial cardiac troponin T and I assays. Comment on: Am J Clin Pathol. 2010 Jan;133(1):14-23. Cardiac troponin T elevations, using highly sensitive assay, in recreational running depend on running distance. No effect of rosuvastatin on left ventricular hypertrophy in patients with hypertension A prospective randomised open-label study with blinded endpoint assessment. Inflammation, overhydration and cardiac biomarkers in haemodialysis patients: a longitudinal study. Cystatin C a marker for renal function after exercise. Three-dimensional flow-through protein platform. Haemodialysis patients longitudinally assessed by highly sensitive cardiac troponin T and commercial cardiac troponin T and cardiac troponin I assays. The role of troponin T in the quantification of ischemic injury Implications of cardiac troponin T degradation Clinical Implementation of serological markers in heart failure How well do laboratories follow guidelines on cardiac markers? The cardiac marker guideline uptake in Europe study. A pilot survey of the use and implementation of cardiac markers in acute coronary syndrome and heart failure across Europe. The CARdiac MArker Guideline Uptake in Europe (CARMAGUE) study. Pharmacokinetics of C1-inhibitor protein in patients with acute myocardial infarction. Continuous 48-h C1-inhibitor treatment, following reperfusion therapy, in patients with acute myocardial infarction. Creatine kinase isoenzyme MB (CKMB) controversy: perimortal tissue acidosis may explain the absence of CKMB in myocardium at autopsy. Effect of acute phase response on cumulative troponin T release. Enhanced preoperative C-reactive protein plasma levels as a risk factor for postoperative infections after cardiac surgery. Fatty acid-binding protein and the early detection of acute myocardial infarction. Cumulative troponin T release after acute myocardial infarction. Influence of reperfusion. Is urinary sulfate a biomarker for the intake of animal protein and meat? Fatty acid-binding protein as marker of muscle injury: experimental findings and clinical application. Capillary electrophoresis of serum proteins. Reproducibility, comparison with agarose gel electrophoresis and a review of the literature. Cardiac troponin T release into plasma after acute myocardial infarction: only fractional recovery compared with enzymes. Distribution of myoglobin and fatty acid-binding protein in human cardiac autopsies. Fatty-acid-binding protein as a plasma marker for the estimation of myocardial infarct size in humans. Developments and changes in clinical chemistry in The Netherlands. Plasma volume determination by use of enzyme dilution in the dog. Quantitative analysis of plasma enzyme levels based upon simultaneous determination of different enzymes. Distribution of enzymes in dog heart and liver; significance for assessment of tissue damage from data on plasma enzyme activities. The two-compartment circulatory model used for enzymatic infarct quantitation. New myocardial marker proteins in acute myocardial infarction. Quantitative aspects Renal dysfunction, hemodialysis, and the NT-proBNP/BNP ratio. High-sensitivity cardiac troponin assays. Laboratory and Clinical aspects The release of cardiac troponin. When, where and how Troponin T Measurements by High-Sensitivity vs Conventional Assays for Risk Stratification in Acute Dyspnea. Evidence-Based Laboratory Medicine: How Well Do Laboratories Follow Recommendations and Guidelines? The Cardiac Marker Guideline Uptake in Europe (CARMAGUE) Study. Cardiac Biomarkers in End-Stage Renal Disease Cardiac and renal markers: reference population versus marathon runners. Proteomic profiling of cerebrospinal fluid to detect potential biomarkers for multiple sclerosis. Troponin, the best there is! High-sensitivity cardiac troponin T: risk stratification tool in patients with symptoms of chest discomfort. Strong link between basal and exercise-induced cardiac troponin T levels: do both reflect risk? A comprehensive review of upper reference limits reported for (high-)sensitivity cardiac troponin assays: the challenges that lie ahead. Multimarker Strategy for Short-Term Risk Assessment in Patients With Dyspnea in the Emergency Department: The MARKED (Multi mARKer Emergency Dyspnea)-Risk Score. Chemokines CCL3/MIP1α, CCL5/RANTES and CCL18/PARC are Independent Risk Predictors of Short-Term Mortality in Patients with Acute Coronary Syndromes. [Cardiac troponin]. The prevalence and management of heart failure in Dutch nursing homes; design of a multi-centre cross-sectional study.